Translational Pharmacology
Animal to Human Equivalent Dose (HED)
HED (mg/kg) = Animal Dose (mg/kg) × [Km(animal) / Km(human)]
Target Output: Human Equivalent Dose (HED)[SOLVED]
0.81081081
mg/kgEstimated human equivalent dose
mg/kg
Dose administered to experimental animal model
Km=3
Body weight to BSA conversion factor (FDA / Reagan-Shaw 2008)
Km=37
Human BSA conversion factor
💡 What This Is Useful For: Determining safe starting doses for Phase I clinical trials and translating promising preclinical in vivo efficacy data to clinical scale.
📐 Real-World Worked Example: A mouse dose of 10 mg/kg (Km = 3) translates to an adult human (Km = 37) equivalent dose: 10 × (3 / 37) ≈ 0.811 mg/kg. For a 70 kg human, this corresponds to roughly 56.8 mg.
⚠️ Preclinical Safety Limit: FDA guidance mandates that HED is solely a starting estimate. Pharmacokinetic differences, receptor affinities, plasma protein binding, and maximum tolerated dose (MTD) toxicology studies must guide clinical protocol designs.
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Scientifically reviewed by:D Yap, MBiochem (Oxon), DIC, PhD (Lond)
Clinical Medicine Research Scientist · LinkedIn Profile ↗
⚠️ Research Reference Notice: For reference and research education only. Reviewer is a clinical medicine research scientist and not a practicing physician or veterinarian, and does not provide clinical certification or medical advice. Experimental drug doses and clinical measurements must be verified against institutional protocols, primary manufacturer labeling, and physician orders.